HLA-E, A Novel Immune Checkpoint
Recently, a team from West China Hospital of Sichuan University published a research paper. In this article, the team found a new immune checkpoint between circulating tumor cells (CTCs) and…
Recently, a team from West China Hospital of Sichuan University published a research paper. In this article, the team found a new immune checkpoint between circulating tumor cells (CTCs) and…
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD). The US Centers for Disease Control and Prevention project that 47% of…
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Intersetingly, Chloroquine not only a excellent anti-inflammatory agent, but also demonstrates more activities about cancer,…
Oxidative stress describes an imbalance between reactive oxygen species (ROS) synthesis and antioxidants. Normally, cells possess antioxidant defense systems that include ROS degrading molecules (ROS scavengers), such as uric acid,…
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. While…
HIFs (Hypoxia-inducible factors) are transcription factors that respond to changes in available oxygen in the cellular environment, to be specific, to decreases in oxygen, or hypoxia. The HIF signaling cascade…
The retinoic acid X receptor (RXR) is a core member of the nuclear receptor protein family. Acts as a ligand-regulated transcription factor. RXR, the heterodimeric partner of VDR, is a…
Darapladib is an orally active, selective and reversible Lp-PLA2 inhibitor, with an IC50 value of 0.25 nM.
p53 (Tumor protein P53; cellular tumor antigen p53; transformation-related protein 53 (TRP53)) is a regulatory protein. The p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such,…