Arimoclomol is an Orally Active Co-Inducer of Heat Shock Proteins (HSP)
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the…
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the…
AdipoR1 and AdipoR2 contain seven-trans membrane Domains. But to be structurally and functionally distinct from G-protein-coupled receptor. It is reported that AdipoR1 activates the AMPK pathways and AdipoR2 activates the…
GLP-1 (Glucagon-Like Peptide-1 Receptor) is a gastrointestinal hormone. Generally speaking, intestinal L cells produce GLP-1, which regulates blood glucose primarily via stimulation of glucose-dependent insulin release. In addition to insulin-releasing…
The transport of pyruvate into the mitochondria plays an important role in glucose oxidation, lipogenesis, and gluconeogenesis. It is also important for the metabolism of some amino acids. In previous…
Noninsulin-dependent diabetes mellitus (type 2 diabetes) is becoming an epidemic disease due to the increased incidence of obesity. Mitsugumin 53 (MG53), tripartite motif-containing protein 72 (TRIM72), larges exist in skeletal…
Macrophage polarization is a process by which macrophages carry out various functional programs responding to signals. Pyruvate Dehydrogenase Kinase (PDK) is a kinase, phosphorylates pyruvate dehydrogenase with ATP to cause…