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BRD5631 Enhances Autophagy through an mTOR-Independent Pathway
Scientists have demonstrated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. And the findings motivate the use of small-molecule probes to study the effects of autophagy on disease-associated…
ML303, a Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonist
In our previous blog “JNJ4796, An Oral Influenza Virus Inhibitor, Mimics the Functionality of bnAbs”, we introduced a novel as an oral active fusion inhibitor of influenza virus, neutralizing influenza…
MLT-748, an Allosteric MALT1 Inhibitor, is a Molecular Corrector to Rescue Function in Immunedeficiency
In previous blog “MLT-747, an Allosteric MALT1 Inhibitor for Immunodeficiency Research”, we introduced MLT-747 as a potent, selective, allosteric inhibitor of MALT1, which could rescue function in an immune deficient…
MLT-747, an Allosteric MALT1 Inhibitor for Immunodeficiency Research
Immunodeficiency is a state, in which the immune system’s ability is absent. It is not able to fight against cancer or infectious diseases. MALT1 is the human paracaspase, with the…
BIBF0775 is a TGFβRI Inhibitor
Transforming growth factor β (TGFβ) is a pluripotent cytokine in the regulation of various biological processes. Inhibition of TGFβ type I receptor offers a novel approach for the treatment of…
FT895 is a Potent and Selective HDAC11 Inhibitor
Histone deacetylases (HDACs) control protein acetylation levels. HDACs catalyze the removal of acetyl groups that are responsible for the addition of acetyl groups. The 11 HDAC family members require zinc…
Dapansutrile, a NLRP3 Inflammasome Inhibitor
The NLRP3 inflammasome is an intracellular oligomer regulating the activation of caspase-1 for the processing and secretion of IL-1β and IL-18. Although there is growing evidence to substantiate inflammasome inhibition…
ZL0454 is a BRD4 Inhibitor for Blocking TLR3-induced Acute Airway Inflammation
As we mentioned in our previous blog “ZL0420 is a BRD4 Inhibitor for Blocking TLR3-induced Acute Airway Inflammation”. Diseases characterized by airway inflammation, excessive airway secretion, and airway obstruction affect…
ABBV-4083 Has Potent Anti-Wolbachia and Anti-filarial Activity
Lymphatic filariasis and onchocerciasis are parasitic helminth diseases that constitute a serious public health issue in tropical regions. In onchocerciasis, disease manifestations mainly arise in the skin-the tissue parasitised by…