HX630 is a Potent RXR Agonist for Cushing’s Diseases Research
The retinoic acid X receptor (RXR) is a core member of the nuclear receptor protein family. Acts as a ligand-regulated transcription factor. RXR, the heterodimeric partner of VDR, is a…
The retinoic acid X receptor (RXR) is a core member of the nuclear receptor protein family. Acts as a ligand-regulated transcription factor. RXR, the heterodimeric partner of VDR, is a…
p53 (Tumor protein P53; cellular tumor antigen p53; transformation-related protein 53 (TRP53)) is a regulatory protein. The p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such,…
Sirtuin (Sir2 proteins) is a class of proteins. And it possesses either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in…
HIV is a virus that affects the immune system. HIV infects important cells in the human immune system, such as helper T cells (especially CD4+T cells), macrophages, and dendritic cells.…
Melittin is the main component of bee venom and the main pain-causing substance that can cause allergic reactions. When injected into animals and humans Melittin causes nociception and activates pain…
Protein kinase C (PKC) is a family of protein kinase enzymes with 15 isoforms that can regulate the protein function. PKCs can control the function of otherproteins through the phosphorylation…
Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins contain five domains, including…
AdipoR1 and AdipoR2 contain seven-trans membrane Domains. But to be structurally and functionally distinct from G-protein-coupled receptor. It is reported that AdipoR1 activates the AMPK pathways and AdipoR2 activates the…
Lipoic acid can be used as a coenzyme to participate in the acyl transfer of material metabolism in the body. Besides, lipoic acid can eliminate free radicals, which leads to…
Cancer initiation and progression are mediated through dysregulation of multiple signaling pathways. Specificity protein 1 (Sp1) is a zinc-finger transcription factor that regulates multiple cellular functions and promotes tumor progression…