Manzamine A, an Orally Active β-carboline Alkaloid, Inhibits GSK-3β and CDK-5
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase ubiquitously expressed and involved in the regulation of many cell functions. GSK-3 phosphorylates the microtubule-associated protein tau in mammalian cells. This hyperphosphorylation…