J-113863 is a CCR1 Antagonist for Rheumatoid Arthritis Treatment
The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
The CC-type chemokine receptor 1 (CCR1) is a chemokine receptor of significant importance in human health. CCR1 is a protein that in humans is encoded by the CCR1 gene. Moreover,…
Renal ischemia/reperfusion injury (IR) is a major clinical problem found in shock, renal transplantation and other clinical settings. Neutrophils and macrophages rapidly infiltrate the kidney after renal ischemia-reperfusion injury. Chemokines…
Monocyte chemoattracant-1 (MCP-1) stimulates leukocyte chemotaxis to inflammatory sites, such as rheumatoid arthritis, atherosclerosis, and asthma, by use of the MCP-1 receptor, CCR2. CCR2 is also a member of the…
Neuroinflammation is an inflammatory response within the brain or spinal cord. The production of cytokines, chemokines, reactive oxygen species, and secondary messengers mediate this inflammation Neuroinflammation occurs as a consequence…
Atopic dermatitis (AD), also known as atopic eczema, is a type of inflammation of the skin (dermatitis). The disease typically begins in early childhood, and patients usually develop into atopic…
Chemokines act as chemoattractants to guide the migration of cells. They play critical roles in immune response. Notably, one chemokine could bind to many receptors, and various chemokines also could…
Human respiratory syncytial virus (RSV) is a single-stranded, negative-sense RNA virus belonging to the Paramyxoviridae family. Unfortunately, RSV usually causes childhood acute lower respiratory infection and produces severe disease at…