PLX5622 is a Selective CSF1R Inhibitor and Can be Used for Microglia Clearance
PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cell elimination, preceding and during pathology development. Additionally, PLX5622 demonstrates…