AS2863619, a Foxp3 Inducer, is an Orally Active CDK8/19 Inhibitor
AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. AS2863619…