CU-115 is a Selective TLR8 Antagonist
Nucleic acid (NA) sensors are part of the innate immune system. they can recognize multiple forms of intracellular self and nonself RNA and DNA macromolecules. Besides, the activation of NA…
Nucleic acid (NA) sensors are part of the innate immune system. they can recognize multiple forms of intracellular self and nonself RNA and DNA macromolecules. Besides, the activation of NA…
Innate immunity is the first-line cellular stress response. Additionally, it is a good way for defending the host cell against invading pathogens. These processes involve pathogen-associated molecular patterns (PAMPs) through…
Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and antiproliferative effects. Specifically, identification of the mechanisms of resistance for…
Motolimod (VTX-2337) is a selective Toll-like receptor (TLR) 8 agonist. In vitro, HEK293 cells with various human TLRs, only Motolimod activates TLR8, Meanwhile, Imiquimod and CpG ODN2006 selectively activate TLR7 and…
Janus kinases are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Particularly, the JAK inhibitors offer a new pharmacological strategy…
Prostaglandin EP2 receptor (PGE2) is a potential neuroprotection target in epilepsy and other inflammation-related neurological disorders. Activation of PGE2 subtype EP2 promotes inflammation. The EP2 receptor widely expresses in both…