PF-184 is a Potent and Selective IKK2 Inhibitor
IKK (IκB kinase) is an enzyme complex that is the core element of the NF-κB cascade. The complex has two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. IKKα…
IKK (IκB kinase) is an enzyme complex that is the core element of the NF-κB cascade. The complex has two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. IKKα…
IKK {IκB kinase} family plays a indispensable role in innate immunity by inducing NF-κB- and IRF -dependent gene transcription programmes required for the production of pro-inflammatory cytokines and IFNs. A…
NF-κBs are homo- or heterodimers of the structurally related subunits p65 (RelA), RelB, cRel, p50 and p52. NF-κB plays a key role in regulating the immune response to infection. NFκBs…