YM-341619 is an Orally Active STAT6 Inhibitor
Naive CD4+ T helper (Th) cells can differentiate into two distinct subsets, Th2 and Th1. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, and control humoral immunity against parasites and…
Naive CD4+ T helper (Th) cells can differentiate into two distinct subsets, Th2 and Th1. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, and control humoral immunity against parasites and…
IRAK4 (interleukin-1 receptor-associated kinase 4) is a protein kinase in the IRAK family. Specifically, IRAK-4 is relevant to signal transduction of innate immune response from toll-like receptors. It also supports…
Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions. NF-κB serves as a pivotal mediator of…
Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein encoded by the CCR8 gene in the human body. Besides, CCR8 is the chemokine receptor of CCL1. Moreover,…
Toll-like receptors belong to a family of pattern recognition receptors, regulate innate immunity and subsequent adaptive immune responses. TLRs can up-regulate costimulatory molecules on antigen-presenting cells (APCs) to activate adaptive…
Toll-like receptors (TLRs) are type I membrane glycoproteins. They contain intracellular Toll–IL-1 receptor homology (TIR) domains. TLRs recognize a wide range of ligands including lipopolysaccharide, double-stranded RNA and lipoprotein. TLRs…
Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and antiproliferative effects. Specifically, identification of the mechanisms of resistance for…
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…
In the NLR family, the NLRP3 inflammasome plays essential roles in the maturation and production of IL-1β and IL-18. Dysregulation of inflammasome and IL-1β affects the pathogenesis of many human…
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily of receptors for signaling molecules, ligands Many ligands, including hormones,…