SB-435495 is an Orally Active Lp-PLA2 Inhibitor for Diabetes Research
Lp-PLA2 (Lipoprotein-associated phospholipase A2) is a calcium-independent serine lipase of 50-kDa that hydrolyzes the acetyl group at the sn-2 position of the platelet-activating factor. Importantly, Lp-PLA2 circulates in plasma bound…