Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
Remibrutinib is a potent and orally active BTK inhibitor for Chronic urticaria (CU) research.
Toll-like receptors 7 and 8 (TLR7/8) are receptors for single-stranded RNA that reside in the endosome. TLR8 mainly expresses in neutrophils, monocytes, and myeloid dendritic cells. While TLR7 exists in…
SLE is a complex autoimmune inflammatory disease that affects multiple organs with unpredictable flares. Autoantibody/antigen immune-complexes in turn can activate TLR7 and/or TLR9 in plasmacytoid dendritic cells (pDCs) leading to…
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. Firstly, in B16-F10 melanoma cells, 3M-011 treatment can decrease B16-F10 melanoma cell counts as a dose-dependent manner. 3M-011 potentiates…
Toll-like receptors belong to a family of pattern recognition receptors, regulate innate immunity and subsequent adaptive immune responses. TLRs can up-regulate costimulatory molecules on antigen-presenting cells (APCs) to activate adaptive…
Chronic hepatitis C (CHC) virus infection continues to be a significant health burden, and 2–3% of the global population infected by the hepatitis C virus (HCV). The innate immune response…
Toll-like receptor (TLR) family proteins belong to PRRs. They play a crucial role in the initiation of the hosts’ immune responses, linking innate immunity and adaptive immunity. TLRs recruit a…
The innate immune system senses the presence of pathogen associated molecular patterns (PAMPs) through a wide variety of germ-line encoded host sensors. They are pattern recognition receptors (PRRs). Toll-like receptor…
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRR). They play an essential role in coordinating innate and adaptive immunity to protect the host from bacteria, viruses, other…
Toll-like receptors (TLRs) are type I transmembrane proteins. They can recognize pathogen-derived macromolecules, thereby playing a key role in the innate immune system. TLR dimerization leads to the activation of…