ZAP-180013 Inhibits the ZAP-70 SH2 and Immunoreceptor Tyrosine-Based Activation Motif (ITAMs) Interaction
ZAP-70 is a 70-kDa ζ-chain CD3 receptor protein tyrosine kinase that operates in the T-lymphocyte signalling pathways. The stimulation of the T-cell receptor triggers the T-lymphocyte signalling pathways. Particularly, ZAP-70…