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TAS6417 is a pan-Mutation Selective EGFR Inhibitor

2021-01-20 Edward Jenner

Despite dramatic response to first and second-generation EGFR TKIs, resistance emerges over time. The EGFR-T790M mutation accounts for more than…

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Posted in: Cancer Immunotherapy Filed under: EGFR, NSCLC, TKI

Neratinib is an Orally Available, Irreversible Tyrosine Kinase Inhibitor

2021-01-19 Edward Jenner

Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…

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Posted in: Cancer Immunotherapy Filed under: Breast Cancer, EGFR, HER

KMH-233 is a Reversible and Selective LAT1 Inhibitor

2021-01-18 Edward Jenner

Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…

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Posted in: Cancer Immunology Filed under: Anti-proliferative, Anti-Tumor, Breast Cancer, LAT1

AG-1478 is a Selective EGFR Tyrosine Kinase Inhibitor

2021-01-16 Edward Jenner

Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is…

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Posted in: Cancer Immunotherapy, EMCV, HCV, Viral Immunology Filed under: A549, DU145, EGFR, EMCV, HCV

Poziotinib is an Orally Active and Irreversible pan-HER Inhibitor

2021-01-15 Edward Jenner

The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family.…

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Posted in: Cancer Immunotherapy Filed under: Antitumor, Apoptosis, EGFR, HER, SNU216

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  • TAS6417 is a pan-Mutation Selective EGFR Inhibitor 2021-01-20
  • Neratinib is an Orally Available, Irreversible Tyrosine Kinase Inhibitor 2021-01-19
  • KMH-233 is a Reversible and Selective LAT1 Inhibitor 2021-01-18

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