Despite dramatic response to first and second-generation EGFR TKIs, resistance emerges over time. The EGFR-T790M mutation accounts for more than…
Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…
Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…
Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is…
The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family.…