MAPKs include many serine-threonine kinases. One of the major MAPK cascades is p38 MAPKs. p38 MAPK can serve as a potential therapeutic target for the treatment of not only inflammatory…
RORγt is a transcription factor of the RAR-related orphan nuclear receptor (ROR) family. It often expresses in Th17 cells and plays an important role in TH17 cell differentiation. RORγt can…
Diacylglycerol kinases are lipid kinases that phosphorylate DAG to generate phosphatidic acid (PA). In mammals, there are ten isoforms of DGKs. R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM)….
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive fibrosis and respiratory failure. Endoplasmic reticulum stress (ER stress) implicates in the pathogenesis of idiopathic pulmonary fibrosis. ER stress activates a…
Protein–protein interactions are major regulators of cell biology and important targets in drug discovery. Specifically, protein-protein interactions are driven by a small set of contact residues. Besides, small molecules that…