STING is a protein with four putative transmembrane domains and resides in the endoplasmic reticulum. STING widely expresses in both immune cells (including innate immune cells and adaptive immune cells)…
Histone deacetylases (HDACs) and RNA polymerase III (POLR3) play vital roles in fundamental cellular processes. In particular, POLR3 mediates transcription of non-coding RNAs. ML-60218 is a potent and selective inhibitor…
Innate immunity is the first-line cellular stress response. Additionally, it is a good way for defending the host cell against invading pathogens. These processes involve pathogen-associated molecular patterns (PAMPs) through…
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key node in innate inflammatory signaling. It is also directly downstream of the Toll-like receptors (TLRs) and interleukin-1 (IL-1) family of receptors. Besides,…
Neutral sphinghomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of sphingomyelin to phosphorylcholine and ceramide. DPTIP, a potent brain penetrant…