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Up to date immunology information.

Fosmanogepix is an Orally Active Gwt1 Inhibitor with Antifungal Activity

Fosmanogepix is an Orally Active Gwt1 Inhibitor with Antifungal Activity

2019-12-11 Edward Jenner
Fosmanogepix is an Orally Active Gwt1 Inhibitor with Antifungal Activity 2019 12 11 - Fosmanogepix is an Orally Active Gwt1 Inhibitor with Antifungal Activity

Invasive pulmonary aspergillosis (IPA) is the leading cause of mold infections in the immunocompromised host. Despite the current aggressive antifungal therapy, IPA still results in a high percentage of fatalities…

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CC-92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity

CC-92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity

2019-12-10 Edward Jenner
CC 92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity 2019 12 10 - CC-92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity

Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and antiproliferative effects. Specifically, identification of the mechanisms of resistance for…

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M-525 is a First-in-class, Irreversible and Covalent Menin-MLL Protein-Protein Interaction Inhibitor

M-525 is a First-in-class, Irreversible and Covalent Menin-MLL Protein-Protein Interaction Inhibitor

2019-12-08 Edward Jenner
M 525 is a First in class Irreversible and Covalent Menin MLL Protein Protein Interaction Inhibitor 2019 12 08 - M-525 is a First-in-class, Irreversible and Covalent Menin-MLL Protein-Protein Interaction Inhibitor

Menin is a protein encoded by the MEN1 gene. MLL fusion proteins interact directly with menin to regulate the expression of MEIS1 and HOX genes, which drive leukemogenesis in MLL…

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PXS-5120A is an Irreversible LOXL2/3 Inhibitor with Anti-Fibrotic Activity

PXS-5120A is an Irreversible LOXL2/3 Inhibitor with Anti-Fibrotic Activity

2019-12-07 Edward Jenner
PXS 5120A is an Irreversible LOXL2 3 Inhibitor withA nti Fibrotic Activity 2019 12 07 - PXS-5120A is an Irreversible LOXL2/3 Inhibitor with Anti-Fibrotic Activity

Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-linking in extracellular matrix proteins (collagen and elastin). There are five members of the human LOX protein…

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GSK484 is a Selective and Reversible PAD4 Inhibitor

GSK484 is a Selective and Reversible PAD4 Inhibitor

2019-12-06 Edward Jenner
GSK484 is a Selective and Reversible PAD4I nhibitor 2019 12 6 - GSK484 is a Selective and Reversible PAD4 Inhibitor

Citrullination of arginine residues, catalyzed by five closely-related protein arginine deiminases (PADs 1-4 and PAD6), affects numerous physiological and pathological processes. Multiple tumors over-express PAD4, and it affects p53 function…

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  • Fosmanogepix is an Orally Active Gwt1 Inhibitor with Antifungal Activity 2019-12-11
  • CC-92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity 2019-12-10
  • M-525 is a First-in-class, Irreversible and Covalent Menin-MLL Protein-Protein Interaction Inhibitor 2019-12-08

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