Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through the site-specific formation of phosphatidylinositol ,5-bisphosphate (PI4,5P2). Numerous pain-producing (pronociceptive) receptors signal via…
Host cellular endoplasmic reticulum (ER) α-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins. They use the calnexin mediated folding pathway. Inhibition of these glycan…
Proteasomes control several cellular processes. They regulate protein degradation, mediate protein homeostasis. Proteasome function is tuned between a ubiquitously expressed constitutive proteasome and an immuno-optimized form, or immunoproteasome. The constitutive…
Persistent or reactivated signaling by the androgen receptor drives the progression of prostate cancer to a deadly form of the disease, namely metastatic castration-resistant prostate cancer (mCRPC). The RAR-related orphan…
Influenza A viruses (IAVs) are negative-sense, single-stranded, segmented RNA viruses from the Orthomyxoviridae family. Moreover, Influenza A viruses cause respiratory infections that range from asymptomatic to deadly. Furthermore, Influenza A viruses…