Invasive pulmonary aspergillosis (IPA) is the leading cause of mold infections in the immunocompromised host. Despite the current aggressive antifungal therapy, IPA still results in a high percentage of fatalities…
Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and antiproliferative effects. Specifically, identification of the mechanisms of resistance for…
Menin is a protein encoded by the MEN1 gene. MLL fusion proteins interact directly with menin to regulate the expression of MEIS1 and HOX genes, which drive leukemogenesis in MLL…
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-linking in extracellular matrix proteins (collagen and elastin). There are five members of the human LOX protein…
Citrullination of arginine residues, catalyzed by five closely-related protein arginine deiminases (PADs 1-4 and PAD6), affects numerous physiological and pathological processes. Multiple tumors over-express PAD4, and it affects p53 function…