Apolipoprotein E (ApoE) is a protein involved in human fat metabolism. Specifically, ApoE belongs to a family of fat binding proteins called apolipoproteins. In the circulation, it exists as part of several types of lipoprotein particles, including chyloparticulate residues, VLDL, IDL, and some HDL. Besides, it is relevant to Alzheimer’s disease and cardiovascular disease. In the central nervous system, astrocytes mainly produced ApoE. Moreover, the cholesterol is into neurons through the ApoE receptor. Interestingly, it is a member of the low-density lipoprotein receptor gene family. ApoE is a major apolipoprotein in response to brain injury, which regulates several components of the TBI related neuroinflammatory cascade. Furthermore, ApoE exerts neuroprotective effects in response to a variety of mechanisms resulting in neuronal injury. Meanwhile, these mechanisms include antioxidant, anti-inflammatory, anti-excitatory, and neurotrophic mechanisms. ApoE is the main cholesterol carrier in the brain. COG1410 is a peptide with neuroprotective and anti-inflammatory effects.
COG1410 is a peptide with neuroprotective and anti-inflammatory effects.
Today, Let’s study how does COG1410 work together. In the beginning, COG1410 exerts neuroprotective and anti-inflammatory effects in a murine model of traumatic brain injury (TBI). Particularly, COG1410 has related to the research of the neurological disease.
In the second place, COG1410 with 1-25 μM for 48 h decreases the production and release of NO and TNFα in BV2 microglia cells. Nonetheless, COG1410 with 0.3-0.6 mg/kg by a single i.v. exhibits significant improvement on a short term test of vestibulomotor function. Importantly, there is the same improvement on a long term test of spatial learning and memory in mice. COG1410 suppresses the microglial activation. Importantly, COG1410 significantly improves cognitive impairment. COG1410 reduces the number of injured hippocampal neurons. By the way, COG1410 improves vestibulomotor function, decreases poststroke locomotor asymmetry. In particular, COG1410 decreases the infarct volume of the ipsilateral hemisphere in rats.
All in all, COG1410 is an apolipoprotein E-derived peptide with neuroprotective and anti-inflammatory effects in a murine model of TBI.
Laskowitz DT, et, al. J Neurotrauma. 2007 Jul;24(7):1093-107.