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Tag: COPD

IHMT-PI3Kδ-372 is a Potent and Selective PI3Kδ Inhibitor

2021-01-06 Edward Jenner

PI3Kδ belongs to the class I Phosphoinositide 3-kinases (PI3Ks). PI3Kδ plays a critical role in chronic obstructive pulmonary disease (COPD).…

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Posted in: Chronic Obstructive Pulmonary Disease, Inflammation Filed under: AKT, COPD, PI3K, PI3Kδ

CP-471474 is an Orally Active and pan MMP Inhibitor

2020-09-02 Edward Jenner

Matrix metallopeptidases (MMPs) are a kind of metalloproteinase which belongs to calcium-dependent zinc endopeptidase. Specifically, these enzymes can degrade all…

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Posted in: Chronic Obstructive Pulmonary Disease Filed under: COPD, MMP

PF-610355 is a Long-Acting Inhaled β2-Adrenoreceptor Agonist

2020-05-23 Edward Jenner

β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind…

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Posted in: Asthma, Chronic Obstructive Pulmonary Disease Filed under: Adrenoreceptor, COPD, Long-Acting

Valategrast is an Orally Active Integrin α4β1 and α4β7 Antagonist

2020-04-08 Edward Jenner

Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of…

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Posted in: Asthma Filed under: COPD, Integrin, VAL-4, α4β1, α4β7

PF-00356231 is a Dual MMP12 and MMP13 Inhibitor

2019-12-19 Edward Jenner

Matrix metalloproteinases (MMPs) are a family of Zn2+-binding, Ca2+-dependent endopeptidases. They play a prominent role in the physiological and pathological…

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Posted in: Chronic Obstructive Pulmonary Disease Filed under: Anti-Inflammatory, COPD, MMP12, MMP13

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