cPLA2α is an intracellular calcium dependent PLA2. It is expressed in a wide variety of tissues and cells. Firstly, cPLA2α can catalyze the release of arachidonic acid (AA) from phospholipids…
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase. Specifically, the enzyme is a key regulator of many signaling pathways. It includes cellular responses to Wnt, receptor tyrosine kinase,…
Liver fibrosis is the accumulation of connective tissue in the liver. The consequence results from an imbalance between production and degradation of the extracellular matrix. Because inflammation histologically presents in…
Nonsteroidal anti-inflammatory agents (NSAIDs) are useful for the treatment of inflammatory diseases. In particular, NSAIDs inhibit the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid to prostaglandins (PGs)…