Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed tissue. Especially, BIO1211 acts as a probe to assess α4β1…
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS) and is a leading cause of chronic neurological disability. The most remarkable hallmarks of MS are…
The ubiquitin-proteasome system exerts numerous essential regulatory functions in almost all cell biological pathways. The 26S proteasome degrades polyubiquitylated protein substrates and consists of a 19S regulator bearing ubiquitin receptors…