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Tag: IFN-γ

CL075 is a Selective TLR8 Agonist with Immunomodulating Properties

2020-11-03 Edward Jenner

Toll-like receptors (TLRs) are a group of pattern recognition receptors for innate immune cells to detect various pathogen-associated molecular patterns.…

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Posted in: Immunology Filed under: IFN-γ, IL-6, IL-8, MyD88, TLR8

BIO-1211 is a Highly Selective and Orally Active α4β1 (VLA-4) Inhibitor

2020-08-27 Edward Jenner

Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed…

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Posted in: Autoimmune Disorders, Encephalomyelitis, Inflammation Filed under: EAE, Encephalomyelitis, IFN-γ, IL-17, Integrin, TNF-α, VLA-4, α4β1

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