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Tag: IFN

G140 is a Potent and Selective cGAS Inhibitor

2020-09-16 Edward Jenner

Innate immunity is the first-line cellular stress response. Additionally, it is a good way for defending the host cell against…

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Posted in: Inflammation Filed under: cGAS, IFN, THP1

CC-92480 is a Cereblon E3 Ubiquitin Ligase Modulating Drug with Antimyeloma Activity

2019-12-10 Edward Jenner

Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and…

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Posted in: Immunology, Immunotherapy Filed under: Anti-Tumor, Apoptosis, CELMoD, IFN, Interleukin, Myeloma, T Cell

Motolimod is a Selective TLR8 Agonist

2019-10-25 Edward Jenner

Motolimod (VTX-2337) is a selective Toll-like receptor (TLR) 8 agonist. In vitro, HEK293 cells with various human TLRs, only Motolimod activates…

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Posted in: Immunotherapy Filed under: IFN, Interleukin, TLR, TNF

BMS-986165 is a Highly Selective and Orally Active TYK2 Inhibitor for Autoimmune Diseases Treatment

2019-08-20 Edward Jenner

Janus kinases are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2…

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Posted in: Autoimmune Disorders, Psoriasis, Skin Inflammation, Systemic Lupus Erythematosus Filed under: IFN, TYK

TG4-155 is a Brain Penetrant EP2 Receptor Antagonist

2019-07-31 Edward Jenner

Prostaglandin EP2 receptor (PGE2) is a potential neuroprotection target in epilepsy and other inflammation-related neurological disorders. Activation of PGE2 subtype…

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Posted in: Epilepsy, Inflammation Filed under: Anti-Inflammatory, Cytokine, IFN

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