Neutral sphinghomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of sphingomyelin to phosphorylcholine and ceramide. DPTIP, a potent brain penetrant…
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS) and is a leading cause of chronic neurological disability. The most remarkable hallmarks of MS are…
mPGES-1 is the terminal enzyme one-step downstream of COX2. It also is the unstable peroxide intermediate from arachidonate catabolism. mPGES-1 can be induced by various inflammatory stimuli in normal cells,…
NOD2 (nucleotide-binding oligomerization domain 2) is an intracellular pattern recognition receptor. NOD2 is one of cytoplasmic PRRs, and antigen-presenting cells and certain mucosal epithelia primarily express it. It assembles with…