![](https://www.Immune-System-Research.com/"wp-content/uploads"/2022/11/22.11.24-GDC-2394-NLRP3-inhibitor.jpg)
Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host’s…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2022/02/OXSI-2-is-an-Oxindole-Syk-Inhibitor-2022-02-25-01-1600x915.png)
Spleen tyrosine kinase (Syk) is a 72 kDa non-receptor tyrosine kinase. Specifically, Syk is activated by binding the tandem SH2…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/CU-115-is-a-Selective-TLR8-Antagonist-2021-02-03.jpg)
Nucleic acid (NA) sensors are part of the innate immune system. they can recognize multiple forms of intracellular self and…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/09/DPTIP-is-a-Brain-Penetrant-N-SMase-2-and-Exosome-Inhibitor-2020-09-12.jpg)
Neutral sphingomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/08/JC-171-is-a-Selective-NLRP3-Inflammasome-Inhibitor-2020-08-05.jpg)
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of the central nervous system (CNS) and is a leading cause of…