Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed tissue. Especially, BIO1211 acts as a probe to assess α4β1…
Retinoic acid-related orphan receptor γt (RORγt) is a nuclear hormone receptor (NHR) and belongs to the RORγ family. It exists in the thymus and contributes to the differentiation of CD4+T…
The transcriptional activity of most nuclear receptors (NRs) can be modulated by small lipophilic molecules such as hormones, vitamins, steroids, and synthetic molecules. The NR1F subfamily of NRs contains the…
Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. In fact, RORs regulate inflammation, metabolic disorders, and circadian rhythm. RORs include RORα…
The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear hormone receptor superfamily. RORs play prominent roles in a variety…