The major cause of cancer mortality is cancer metastasis, which accounts for approximately 90% of deaths. As we all know, most primary tumors are manageable or curable. However, once cancer…
Leukotriene B4 (LTB4) is a lipid mediator with potent chemoattractant properties. Activated innate immune cells such as neutrophils, macrophages, and mast cells rapidly generate LTB4. Ligation of BLT1 by LTB4…
CXCR4 is a chemokine receptor specific to matrix derived factor-1 (SDF-1), which has effective chemotactic activity on lymphocytes. Specifically, CXCR4 is one of several chemokine co receptors that HIV can…
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). Necroptosis closely associates with pathologies including inflammatory diseases, neurodegenerative…