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Tag: Necrosis

PF-543 is a Selective and Reversible SPHK1 Inhibitor

2020-10-06 Edward Jenner

S1P (sphingosine 1-phosphate) is an extracellular ligand at five cognate GPCRs and a consequential intracellular lipid intermediate. It affects diverse…

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Posted in: Cardiovascular Filed under: Apoptosis, Autophagy, Necrosis, PAH, SPHK1

A Dual RIP1/RIP3 Inhibitor GSK2593074A

2019-05-01 Edward Jenner

Receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) are serine/threonine protein kinases. In addition, RIP1 and RIP3 share a…

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Posted in: Inflammation Filed under: Cytokine, Necrosis

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