![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/TAS6417-is-a-pan-Mutation-Selective-EGFR-Inhibitor-2020-01-20.jpg)
Despite dramatic response to first and second-generation EGFR TKIs, resistance emerges over time. The EGFR-T790M mutation accounts for more than…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/04/ZX-29-a-Selective-ALK-Inhibitor-Induces-Apoptosis-via-ER-Stress-2020-04-16.jpg)
Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily. Specifically, the fusion form can activate ALK, and ALK…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/12/Lorlatinib-is-an-Orally-Active-and-Dual-ALK-ROS1-Inhibitor-2019-12-18.jpg)
Oncogenic c-Ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for…