β-Galactosidase, a glycoside hydrolase family, catalyzes the cleavage of glycosidic bonds β-Galactoside is hydrolyzed to monosaccharide. Specifically, β-Galactosidase is a kind of exoglycosidase, which can hydrolyze the protein formed between…
BMS-582949 was identified as a highly selective p38α MAP kinase inhibitor as early in 2010. Moreover, it has entered into clinical trials for further development and clinical studies in inflammatory…
Various types of cytokinesuchemokines react with their receptors. They transduce extracellular signals into intracellular response through a mitogen-activated protein kinase (MAPK) signalling cascade. Furthermore, p38 MAPK signalling might play an…
Currently, a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications. Stress kinases are of special interest in neurological and neuropsychiatric disorders, because of their involvement…
In previous blogs, we have introduced a few MAPK p38 inhibitors. As a result, MAPK p38 plays an important role in many diseases, including cancer and inflammatory diseases. Today, I’d…
A wide range of cellular stresses can activate mammalian p38 MAPKs, or it is in response to inflammatory cytokines. The p38 MAPK subfamily can further be divided into two distinct…
Asthma is a chronic inflammatory disease of the lungs. It is a common disease due to genetic and environmental factors. However, there is no cure for this disease. We can…
The mitogen-activated protein kinase (MAPK) p38a is activated by environmental stimuli, bacterial products and cytokines. It plays a critical role in the production of proinflammatory cytokines such as TNF-a and…