ETA and ETB Receptor are isoforms of endothelin receptor. The ETA receptors on vascular smooth muscle cells mediate vasoconstriction. Otherwise, ETB Receptor is present in both endothelial and vascular smooth…
Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory signal transduction, smooth muscle contraction, oocyte fertilization, and other functions.…
Tropomyosin receptor kinases (Trk) family includes TrkA, TrkB and TrkC, can be activated by hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and…
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel…
Kallikrein (KLK) is a main rate-limiting enzyme of the kinin system. Specifically, Kallikrein cleaves the substrate peptide at the carbon end. It also releases active kinin, which can regulate cardiovascular…
The somatostatin receptor is the receptor of the ligand somatostatin, especially in the postsynaptic response to the costimulation/activation of the NMDA receptor. Specifically, somatostatin is a small neuropeptide related to…
Potent and selective antagonists of the voltage-gated sodium channel Nav1.7 can be a potential method for the development of chronic pain therapies. In this article, we will introduce an atropisomer…