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Tag: PAM

MS48107 is a Selective GPR68 PAM

2020-12-26 Edward Jenner

G protein-coupled receptor 68 (GPR68) is originally discovered as a clinically related receptor in an ovarian cancer cell line. GPR68…

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Posted in: Neuroimmunology, Neurological Disease Filed under: GPR68, hERG, PAM

AZD7325 is an Orally Active GABAAα2,3 Positive Allosteric Modulator

2020-05-06 Edward Jenner

Benzodiazepines are useful in the research of anxiety disorders. Benzodiazepines also is useful for symptomatic relief of various anxiety states…

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Posted in: Epilepsy Filed under: Anxiety, Dravet, GABA, PAM
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5-HT Anti-Inflammatory Anti-Tumor Antibacterial Antibiotic Antifungal Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Chemokines COPD COVID-19 Cytokine Dopamine EGFR HBV HCV HDAC HIV IFN IL-6 IL-17 Infection Inflammasome Integrin Interleukin IPF JAK Leukemia Low Toxicity Multidrug Resistance NF-κB p38 MAPK PI3K Proteasome RIPK ROS T Cell Th17 TLR TNF TNF-α
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