MYC proteins include MYC (also known as c-MYC), MYCL, and MYCN. They play critical roles in tumorigenesis and therapeutic resistance. MYC proteins are implicated in up to 70% of all human…
The blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer therapy. However, the antibody-based immunotherapies carry a number of disadvantages, including the high…
The transcriptional activity of most nuclear receptors (NRs) can be modulated by small lipophilic molecules such as hormones, vitamins, steroids, and synthetic molecules. The NR1F subfamily of NRs contains the…