Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of PDE are referring to cyclic nucleotide…
Phosphodiesterases (PDEs) are enzymes that convert cyclic nucleotides (cAMP and cGMP) to their corresponding 5′-AMP and 5′-GMP in order to…
Atopic dermatitis (AD) is a chronic inflammatory skin disease. the characterizes of AD are eczematous lesions and intense itching. The…
Cyclic AMP (cAMP) is a universal second messenger in cells of all biological systems. Specifically, cAMP homeostasis is affected by…
Phosphodiesterase-4 (PDE4) acts as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. GSK356278, a potent, selective, brain-penetrant phosphodiesterase…