![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/12/Rolipram-is-a-Selective-Phosphodiesterases-PDE4-Inhibitor-2021-12-03.jpg)
Phosphodiesterases (PDEs) are enzymes that convert cyclic nucleotides (cAMP and cGMP) to their corresponding 5′-AMP and 5′-GMP in order to…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/03/LEO-39652-is-a-Dual-Soft-PDE4-Inhibitor-2021-03-18.jpg)
Atopic dermatitis (AD) is a chronic inflammatory skin disease. the characterizes of AD are eczematous lesions and intense itching. The…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/12/MR-L2-is-a-Reversible-and-Non-competitive-Allosteric-Activator-of-Long-Isoform-PDE4-2020-12-19.jpg)
Cyclic AMP (cAMP) is a universal second messenger in cells of all biological systems. Specifically, cAMP homeostasis is affected by…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/10/GSK356278-is-a-Selective-and-Orally-Bioavailable-PDE4-Inhibitor-2020-10-21.jpg)
Phosphodiesterase-4 (PDE4) acts as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. GSK356278, a potent, selective, brain-penetrant phosphodiesterase…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/07/FCPR03-is-a-Selective-Phosphodiesterase-4-PDE4-Inhibitor-2020-07-21.jpg)
Phosphodiesterase 4 (PDE4) is an enzyme mainly expresses in the central nervous system, smooth muscle, cardiovascular. In neuronal cells, PDE4…