Atopic dermatitis (AD) is a chronic inflammatory skin disease. the characterizes of AD are eczematous lesions and intense itching. The…
Cyclic AMP (cAMP) is a universal second messenger in cells of all biological systems. Specifically, cAMP homeostasis is affected by…
Phosphodiesterase-4 (PDE4) acts as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. GSK356278, a potent, selective, brain-penetrant phosphodiesterase…
Phosphodiesterase 4 (PDE4) is an enzyme mainly expresses in the central nervous system, smooth muscle, cardiovascular. In neuronal cells, PDE4…