mPGES-1 is the terminal enzyme one-step downstream of COX2. It also is the unstable peroxide intermediate from arachidonate catabolism. mPGES-1 can be induced by various inflammatory stimuli in normal cells,…
CXCL17 is a mucosal chemokine that associates with human diseases including idiopathic pulmonary fibrosis (IPF) and cancer. CXCL17 is an antimicrobial mucosal chemokine that may play a role in the…
Prostaglandin E2 is a lipid mediator that contributes to inflammatory pain. Selective inhibitors of microsomal PGE synthase-1 and subtype-selective antagonists of PGE2 receptors, particularly EP1 and EP4, may be useful…