IOX4 is a Highly Selective PHD2 Inhibitor
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further transactivates PHDs. Asparaginyl hydroxylation also regulates HIFα. Asparaginyl hydroxylation is…