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Tag: PHD

IOX4 is a Highly Selective PHD2 Inhibitor

2019-09-17 Edward Jenner

Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further…

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Posted in: Cancer Immunology, Neurological Disease Filed under: HIF, PHD, Stroke
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