ZAP-70 is a 70-kDa ζ-chain CD3 receptor protein tyrosine kinase that operates in the T-lymphocyte signalling pathways. The stimulation of the T-cell receptor triggers the T-lymphocyte signalling pathways. Particularly, ZAP-70…
Annexin A2 (A2) expresses in plants, animals, and protists throughout the phylogenetic tree, it belongs to the annexin family A2 can be produced by endothelial cells, monocytes, macrophages. It is…
Core binding factor (CBF) leukemias account for ∼24% of adult acute myeloid leukemia (AML) and 25% of pediatric acute lymphocytic leukemia (ALL). CBF leukemias show translocations or inversions that affect…
The c-Jun N-terminal kinases (JNKs) are a series of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) family. Besides, protein kinases comprise 2% of the mammalian genome and catalyze…
Protein–protein interactions are major regulators of cell biology and important targets in drug discovery. Specifically, protein-protein interactions are driven by a small set of contact residues. Besides, small molecules that…