Recent research shows that RIP1 kinase activity is an important driver of TNF-mediated inflammation and pathology. Genetic evidence of mice supports it. The mutations shunt signaling down the RIP1 kinase…
In previous blogs, I have introduces several RIPK inhibitors, including RIP1 inhibitors RIPA-56, PK68, GSK547, GNE684, and GSK2982772. But the RIP2 inhibitors are lacked, today, I’d like to make up…
The innate immune system is a key driver of our immune response from birth. It provides an immediate response to foreign invaders. It comprises pattern recognition receptors (PRRs). Toll-like receptors…
Necrosis is the death of cells and tissues. The kinase activity of receptor-interacting protein kinase 1 (RIP1/RIPK1) and/or RIP3/RIPK3 mediates this regulated form of necrosis. These results suggest RIP1 and…
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL). Necroptosis closely associates with pathologies including inflammatory diseases, neurodegenerative…