![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/GSK481-is-a-Mono-Selective-RIP1-Kinase-Inhibitor-2019-09-09.jpg)
Recent research shows that RIP1 kinase activity is an important driver of TNF-mediated inflammation and pathology. Genetic evidence of mice…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/GSK583-is-an-Orally-Active-and-Selective-RIP2-Kinase-Inhibitor-2019-09-03.jpg)
In previous blogs, I have introduces several RIPK inhibitors, including RIP1 inhibitors RIPA-56, PK68, GSK547, GNE684, and GSK2982772. But the…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/GSK2983559-is-a-Specific-and-Oral-Active-RIP2-Kinase-inhibitor-for-Inflammatory-Diseases-2019-09-01.jpg)
The innate immune system is a key driver of our immune response from birth. It provides an immediate response to…
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Necrosis is the death of cells and tissues. The kinase activity of receptor-interacting protein kinase 1 (RIP1/RIPK1) and/or RIP3/RIPK3 mediates…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/07/PK68-a-type-II-Inhibitor-of-RIPK1-Has-potential-to-Treat-Inflammatory-Disorders-and-Cancer-Metastasis-2019-07-28.jpg)
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein…