CD73, also known as 5′-nucleotidase (5′-NT), is commonly used to convert amp to adenosine. Specifically, CD73 is a surface enzyme in multiple cells. The enzyme mediates autocrine and paracrine danger…
Interleukin-2 (IL-2) is a pleiotropic cytokine and controls the differentiation and homeostasis of both pro- and anti-inflammatory T cells. The IL-2 receptor couples to JAK tyrosine kinases and activates the…
ZAP-70 is a 70-kDa ζ-chain CD3 receptor protein tyrosine kinase that operates in the T-lymphocyte signalling pathways. The stimulation of the T-cell receptor triggers the T-lymphocyte signalling pathways. Particularly, ZAP-70…
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone. Specifically, selective HDAC inhibitors are as a potential anti latent…
Hematopoietic progenitor kinase-1 (HPK1) is a serine/threonine Ste20 related protein kinase. It expresses only in hematopoietic cells (such as T cells, B cells, and dendritic cells). Specifically, HPK1 is a…