Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ε-N-acetyl-lysine amino acid on a histone. Specifically, selective HDAC inhibitors are as a potential anti latent…
Hematopoietic progenitor kinase-1 (HPK1) is a serine/threonine Ste20 related protein kinase. It expresses only in hematopoietic cells (such as T cells, B cells, and dendritic cells). Specifically, HPK1 is a…
The BAF (mammalian SWI/SNF) chromatin remodeling complex establishs and maintains viral latency. In particular, BAF (SWI/SNF) is an attractive target for HIV-1 latency reversal. In this study, researchers report a…
Immunomodulatory agents (IMiDs) are a class of immunomodulatory drugs. Thalidomide analogs have induced significant antimyeloma effects via immune-modulation, antiangiogenesis, and antiproliferative effects. Specifically, identification of the mechanisms of resistance for…
In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such as activation, differentiation, effector function, and cell death. Thus, targeting…