Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions. NF-κB serves as a pivotal mediator of…
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143 treatment at different doses in THP-1 cells. GS143 suppresses the…
NF-κB-mediated inflammation is a major pathology in kidney diseases, such as non-kidney inflammatory diseases, and rheumatoid arthritis. HIV infection in the kidney induces NF-κB activation, leading to the production of…
Phospholipases A2 (PLA2s) is enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. Peroxiredoxin 6 (Prdx6)…
The activation of NF-kappa B consists of at least three steps. The processes include degradation of I kappa B alpha, translocation of NF-kappa B into the nucleus, ai post-translational modification…