RAS is the name of a series of related proteins commonly expressed in all cell lineages and organs. Specifically, RAS…
Amyloid beta (Aβ) is a major component of amyloid plaques found in the brains of patients with Alzheimer’s disease. Specifically,…
Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and…
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143…
NF-κB-mediated inflammation is a major pathology in kidney diseases, such as non-kidney inflammatory diseases, and rheumatoid arthritis. HIV infection in…