Phosphodiesterase-4 (PDE4) acts as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 ( PDE4) inhibitor that demonstrates anxiolytic and cognition-enhancing effects…
Nuclear factor-κB (NF-κB) represents a family of inducible transcription factors. The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions. NF-κB serves as a pivotal mediator of…
Very Late Antigen-4 (VLA4 or CD49d/CD29) is aα4β1 integrin with a pivotal role in controlling immune cell migration into inflamed tissue. Especially, BIO1211 acts as a probe to assess α4β1…
Inflammation and cancer are now coupled in treatment approaches by a growing understanding of the dynamic molecular dialogues between immune and cancer cells. McDonough feline sarcoma viral (v-fms) oncogene homolog…
Many immune diseases may result in the excessive production of various inflammatory cytokines as well as cellular injury. Curcumin plays an important role as an anti-inflammatory agent. Due to Curcumin’s…