Sigma Ligands has cytotoxic activity in vitro and is able to induce ceramide/caspase-independent apoptosis. In addition, these ligands down-regulate P-glycoprotein (P-gp) mRNA levels in some mouse and human models. In…
Mycobacterium tuberculosis (Mtb), the primary etiological agent of tuberculosis (TB), has plagued mankind for millennia and remains the leading cause of bacterial infectious disease mortality. Mtb H37Rv is the model…
ZAP-70 is a 70-kDa ζ-chain CD3 receptor protein tyrosine kinase that operates in the T-lymphocyte signalling pathways. The stimulation of the T-cell receptor triggers the T-lymphocyte signalling pathways. Particularly, ZAP-70…
The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia. The genetic disruption of this interaction abrogates the development of acute…
Aminoacyl-tRNA synthetases (ARSs) is an important enzyme and conjugates amino acids to their cognate tRNAs during protein synthesis. In higher eukaryotic systems, ARS-interacting multifunctional proteins (AIMPs) and ARSs form a…
Annexin A2 (A2) expresses in plants, animals, and protists throughout the phylogenetic tree, it belongs to the annexin family A2 can be produced by endothelial cells, monocytes, macrophages. It is…
Chronic hepatitis B (CHB) is a global endemic disease, and an estimated 400 million people have CHB in worldwide. Twenty-five to 40% of these chronically infected people eventually develop hepatocellular…
Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein encoded by the CCR8 gene in the human body. Besides, CCR8 is the chemokine receptor of CCL1. Moreover,…
SpCas9 is an RNA-guided DNA endonuclease and has a facile introduction of genomic alterations. The SpCas9 complex and guide RNA (gRNA) recognizes the substrate sequence via a protospacer adjacent motif…
Hematopoietic stem and progenitor cells (HSPCs) reside means a specialized microenvironment, which regulates self-renewal and differentiation of HSPCs. Hematopoiesis in the adult mouse often exists in spleen and bone marrow.…