Fascin 1 (fascin) is an actin-bundling protein. It cross-links filamentous actin (F-actin) into tightly packed parallel bundles driving the formation of various cell surface protrusions, such as filopodia and invadopodia.…
Sphingosine-1 phosphate (S1P) is a signal sphingolipid, also known as a bioactive liposome. Specifically, S1P is an extracellular factor that acts as an effective lipid mediator by binding with specific…
PI3Ks are key drivers of the survival and growth of normal B cells. PI3K catalyzes the phosphorylation of PI(4,5)P2 to generate PI(3,4,5)P3. It serves as a docking site at the…
Protein lysine methyltransferases (PKMTs, HMTs) are an important target class for modulation to regulate gene expression, cell differentiation, and organismal development. Polycomb repressive complex 2 (PRC2) that catalyzes methylation of…
NADPH oxidases (NOX), catalyzing the reduction of molecular oxygen to form the superoxide radical anion (O₂⁻) and hydrogen peroxide (H₂O₂). NOX involves in several pathological conditions, such as stroke, diabetes,…
Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. MRP4 associates with multidrug resistance (MDR), which is a growing challenge to the treatment of cancer and infections. Therefore,…
Phosphodiesterase-4 (PDE4) acts as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 ( PDE4) inhibitor that demonstrates anxiolytic and cognition-enhancing effects…
Aryl hydrocarbon receptor (AhR) are transcription factors that regulate gene expression. Specifically, AHR proteins contain several domains that are critical for their function. They are members of the basic helix…
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Specifically, malaria caused Symptoms usually including fever, fatigue, vomiting and headache. Besides, malaria is due to the single-celled…
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum-associated stress sensor protein. PERK phosphorylates eukaryotic initiation factor 2α (eIF2α) to induce translation attenuation in response to ER…