RNA-dependent RNA polymerase (RdRp) is an essential enzyme for virus replication and transcription, controlling the two important processes of viral RNA. RdRps catalyzes the formation of phosphodiester bonding between ribonucleotides,…
Immunoglobulin E (IgE) is an immunoglobulin, which plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. Specifically, it is one of the five immunoglobulins (A, G,…
Mast cell stabilizers prevent or control certain allergic disorders. In particular, Lodoxamide is a mast cell stabilizer. Furthermore, Lodoxamide inhibits mast cell degranulation in vitro and in vivo. Lodoxamide is…
Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in IL-4 signaling pathway. STAT6 is also a key regulator of the Th2 cell immune response. Therefore,…
Muscarinic M3 receptors are a subtype of Muscarinic acetylcholine receptors (mAChRs). Specifically, mAChRs is acetylcholine receptor, which forms a G-protein-coupled receptor complex in the cell membrane of some neurons and…
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli. Specifically, AP-1 controls many cellular processes, including differentiation, proliferation, and apoptosis.…
Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2 vitamin D3) binds to VDR and then…
Respiratory syncytial virus (RSV) is an enveloped, single-stranded, negative-sense RNA virus. It belongs to the Pneumovirinae subfamily of Paramyxoviridae. Furthermore, this kind of virus infects the respiratory tract of humans and causes severe…
Matrix metallopeptidases (MMPs) are a kind of metalloproteinase which belongs to calcium-dependent zinc endopeptidase. Specifically, these enzymes can degrade all kinds of extracellular matrix proteins, but they can also process…
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143 treatment at different doses in THP-1 cells. GS143 suppresses the…