Receptor tyrosine kinases are a large family of cell surface receptors responsible for regulating cellular proliferation, differentiation, survival, metabolism, and life cycle. Discoidin domain receptors 1 and 2 (DDR1 and…
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-linking in extracellular matrix proteins (collagen and elastin). There are five members of the human LOX protein…
G protein-coupled receptors (GPCRs) are also known as 7TM receptors due to their transmembrane domains. they constitute the largest superfamily of receptors for signaling molecules, ligands Many ligands, including hormones,…
In cancer, CG-200745 is a novel and potent hydroxamate-based pan-HDAC inhibitor. Moreover, another study from Hong Sang Choi demonstrated that CG200745 attenuates renal fibrosis in obstructive kidney disease. Epigenetic modifications…
The serine hydrolases monoacylglycerol lipase (MAGL) is responsible for degrading 2-arachidonoyl glycerol (2-AG). And the fatty acid amide hydrolase (FAAH) degrades N-arachidonoyl ethanolamine (anandamide or AEA). They are endogenous agonists…