Cathepsin C (CTSC) acts as the key activator of the proenzymes of several neutrophil granule‐associated serine proteases (NSPs). CTSC also plays a role in the activation of other leucocyte‐derived serine…
CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…
Metastasis is the major driver in cancer-related deaths. Metastases involve dysregulation of numerous cellular processes. Importantly, blockade of RhoC prevents cellular invasion in breast and prostate cancer models. Especially, RhoA…
Right ventricular (RV) hypertrophy and failure are the main causes of morbidity and mortality with pulmonary arterial hypertension (PAH) in many patients. In the vascular system, Prostaglandin E2 (PGE2) can…
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive fibrosis and respiratory failure. Endoplasmic reticulum stress (ER stress) implicates in the pathogenesis of idiopathic pulmonary fibrosis. ER stress activates a…