Histamine Receptors are a class of G protein-coupled receptors with histamine as their endogenous ligand. There are four types histamine…
Etrasimod is a potent, selective, and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor. And the IC50 value is 1.88 nM in…
Prostaglandin D2 (PGD2) is a major inflammatory mediator produced by mast cells and Th2 cells. PGD2 is a lipid mediator…
The symptoms of Allergic rhinitis are rhinorrhea, sneezing, nasal pruritus, congestion, and aggravation of comorbid asthma. Histamine can interact with…
C5a is an important inflammatory hypernociceptive mediator, acting by a mechanism independent of hypernociceptive cytokine release, but dependent on the…