DSM705 is a Plasmodium DHODH Inhibitor
Malaria is one of the most widespread and ancient infectious diseases of humanity. In particular, Dihydroorotate dehydrogenase (DHODH) acts as a target for the development of new antimalarials. In addition,…
Ozanimod (RPC-1063) is a Selective S1P1 and S1P5 Receptor Agonist
Sphingosine 1-phosphate (S1P) is a lysophosphatidic mediator, which can activate G protein-coupled sphingosine 1-phosphate receptor. Specifically, this leads to a variety of cellular and tissue responses, including lymphocyte transport, endothelial…
Secukinumab (AIN457) is a Human Monoclonal Antibody Targeted against IL-17A
Interleukin-17 family (IL-17 family) is a pro-inflammatory cystine node cytokine family. After binding to the receptor, IL-17 can activate several signal cascades, leading to the induction of chemokines. As chemokines,…
BI-6901 is a Potent and Selective CCR10 Antagonist
Chemokine receptors are a group of membrane proteins, belong to the seven-transmembrane, G protein-coupled protein superfamily. Chemokines and chemokine receptors regulate tissue-specific migration, maintenance and functions of immune cells. The…
Limaprost, a PGE1 Analogue, is a Potent and Orally Active Vasodilator
Thromboangiitis obliterans (TAO; Buerger's disease) is a non-atherosclerotic, occlusive, inflammatory disease. And it occurs in the distal, small-and medium-size arteries and veins of the arms and legs. Signs and symptoms…
N-Acetylcysteine amide, a Thiol Antioxidant and Neuroprotective Agent, Reduces ROS Production
N-acetylcysteine amide (NACA) is the amide derivative of N-acetylcysteine (NAC) that is rapidly converted to NAC after systemic administration. N-acetylcysteine amide has emerged as a promising thiol antioxidant for multiple…
Simeprevir is an Orally Active HCV NS3/4A Protease Inhibitor
Hepatitis C is a blood-borne infection that can ultimately result in severe liver diseases, including fibrosis, cirrhosis, and hepatocellular carcinoma. The chronic nature of the disease and the significant possibility…
Lodoxamide, an Antiallergic Compound, Acts as a Mast-Cell Stabilizer
Mast cell stabilizers prevent or control certain allergic disorders. In particular, Lodoxamide is a mast cell stabilizer. Furthermore, Lodoxamide inhibits mast cell degranulation in vitro and in vivo. Lodoxamide is…
FAUC 346 is a Highly Selective D3 Partial Agonist
Dopamine receptors are classified into the Gs-coupled D1-like (D1 and D5) and Gi/o-coupled D2-like (D2, D3, and D4) receptor subtypes. FAUC 346 is an in vitro D3-selective ligand. In particular,…