Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.…
The GnRH receptor is a member of the G protein-coupled receptor superfamily with seven predicted membrane spanning helices. Activation of the receptor stimulates phospholipase C and phosphatidyl inositol turnover by…
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family. It is the receptor of gonadotropin-releasing hormone (GnRH). In addition, GnRH receptor…
Sickle cell hemoglobin (HbS) is caused by a mutation that replaces a glutamic acid at residue 6 in beta-globin with a valine. This amino acid substitution results in the formation…
Neurokinin 3 receptor (NK3R) is the most selective of the tachykinin receptors, with highly preferential binding and activation by its endogenous ligand NKB (TAC3). Importantly, NK3R is mainly expressed in…
MPDE5 is an enzyme derived from phosphodiesterases, present in various tissues, including rods and cones of the retina, and belongs to the large family of cyclic nucleotide PDEs that catalyze…
Oxytocin Receptor, also known as OXTR, OTR, is the receptor protein for oxytocin and is encoded by the OTR gene located on human chromosome 3p25. OTR protein belongs to the…
Muscarinic receptor, also known as muscarinic cholinergic/acetylcholine receptor (mAChR), belongs to the G protein-coupled receptor (GPCR) family and is found in many parts of the body, such as brain and…
11β-Hydroxysteroid dehydrogenase type 1 (HSD11β1) is an NADPH-dependent enzyme. In particular, 11β-HSD isozymes are tissue-specific regulators of Glucocorticoid (GC) pre-receptor metabolism. Obviously, it consists of hsd11β1 and hsd111β2 composition. HSD11β1…
L-368,899 is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist. L-368,899 shows IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. Additionally, L-368,899…