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XY018 is a Potent RORγ Selective Antagonist
Persistent or reactivated signaling by the androgen receptor drives the progression of prostate cancer to a deadly form of the disease, namely metastatic castration-resistant prostate cancer (mCRPC). The RAR-related orphan…
CBS1117 is a Virus (Influenza A Viruses) Entry Inhibitor
Influenza A viruses (IAVs) are negative-sense, single-stranded, segmented RNA viruses from the Orthomyxoviridae family. Moreover, Influenza A viruses cause respiratory infections that range from asymptomatic to deadly. Furthermore, Influenza A viruses…
AG-024322 is a Potent ATP-Competitive pan-CDK Inhibitor
Mammalian cell division involves an orderly progression through four distinct phases: G1 (growth phase 1), S (DNA synthesis), G2 (growth phase 2), and M (mitosis). During the G1 phase, cells…
ML188 is a Noncovalent Inhibitor of the SARS-CoV 3CL Protease
Coronaviruses (CoV) are large plus-strand RNA viruses. They cause medical disorders such as the common cold, lower respiratory tract infections, and diarrhea. The SARS-CoV genome encodes a large polyprotein. Two…
PF-610355 is a Long-Acting Inhaled β2-Adrenoreceptor Agonist
β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind of hormone and neurotransmitter and it can enhance the signal…
GSK-2793660 is an Orally Active Inhibitor of Cathepsin C (CTSC)
Cathepsin C (CTSC) acts as the key activator of the proenzymes of several neutrophil granule‐associated serine proteases (NSPs). CTSC also plays a role in the activation of other leucocyte‐derived serine…
IR415, a Potent Anti-HBV Agent , Selectively Targets HBx
Hepatitis B is a serious infectious disease of the human liver caused by the hepatitis B virus (HBV). Meanwhile, HBV infection often becomes chronic. It results in hepatocellular carcinoma (HCC).…