PDE4B is an enzyme that in humans is encoded by the PDE4B gene. Importantly, PDE4B is involved in dopamine-associated and stress-related behaviors. Particularly, study show that reduction in PDE4B activity…
CXCR3, which belongs to the transmembrane G protein-coupled receptor (GPCR) superfamily, is an inflammatory chemokine receptor. This chemokine receptor can regulate immune cell behavior and promote chemotaxis, cell adhesion as…
The inflammasomes are protein complexes. The innate immune sensors, including NOD-like receptor (NLR) family members (NLRP1, NLRP3, and NLRC4) as well as other non-NLR receptors form them. Upon activation, the…
The innate immune system is a key driver of our immune response from birth. It provides an immediate response to foreign invaders. It comprises pattern recognition receptors (PRRs). Toll-like receptors…
CD95L is a transmembrane ligand (m-CD95L) releases a soluble ligand (s-CD95L) that is cleaved by metalloproteases. Unlike m-CD95L, the interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD…
Immunoproteasome plays a critical role in the immune system because it degrades intracellular proteins, for example, those of viral origin, into small proteins. Immunoproteasome is abundantly expressed in immune cells.…
Interferons (IFNs) are a group of signaling proteins in response to the presence of several viruses. Cyclic GMP-AMP Synthase (cGAS, cGAMP synthase) is a cytosolic DNA sensor. Especially, cGAS activates…
The abnormal activation of innate immune pathways partispate in the progress of various diseases. Unfortunately, the development of drugs specifically targeted molecules with interest and potential still remains challenging. A…