![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/10/CY-09-is-a-Selective-and-Direct-NLRP3-Inhibitor-for-Inflammatory-Disorders-Treatment-2019-10-23.jpg)
The inflammasomes are protein complexes. The innate immune sensors, including NOD-like receptor (NLR) family members (NLRP1, NLRP3, and NLRC4) as…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/GSK2983559-is-a-Specific-and-Oral-Active-RIP2-Kinase-inhibitor-for-Inflammatory-Diseases-2019-09-01.jpg)
The innate immune system is a key driver of our immune response from birth. It provides an immediate response to…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/06/DB550-Targeting-PLCγ1-Prevents-Th17-driven-Inflammation-via-Disrupting-the-CD95-PLCγ1-Interaction-2019-06-25.jpg)
CD95L is a transmembrane ligand (m-CD95L) releases a soluble ligand (s-CD95L) that is cleaved by metalloproteases. Unlike m-CD95L, the interaction…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/ONX-0914-a-Selective-Inhibitor-of-the-Immunoproteaome-Subunit-LMP7-Attenuates-Progression-of-Arthritis-2019-05-31.jpg)
Immunoproteasome plays a critical role in the immune system because it degrades intracellular proteins, for example, those of viral origin,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/PF-06928215-a-High-Affinity-Inhibitor-of-cGAS-2019-05-30.jpg)
Interferons (IFNs) are a group of signaling proteins in response to the presence of several viruses. Cyclic GMP-AMP Synthase (cGAS,…