Interleukin-17 family (IL-17 family) is a pro-inflammatory cystine node cytokine family. After binding to the receptor, IL-17 can activate several signal cascades, leading to the induction of chemokines. As chemokines,…
RORγ (gene name RORC) is an orphan nuclear receptor (NR). Various metabolic processes regulate its expression and involvement. Meanwhile, RORγ is also a key player in the immune system. The…
The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear hormone receptor superfamily. RORs play prominent roles in a variety…
BMS-582949 was identified as a highly selective p38α MAP kinase inhibitor as early in 2010. Moreover, it has entered into clinical trials for further development and clinical studies in inflammatory…
Janus kinases are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Particularly, the JAK inhibitors offer a new pharmacological strategy…
Receptor-interacting protein kinase 1 (RIPK1) is an important upstream kinase. Both scaffolding and kinase specific functions of RIPK1 can regulate inflammation. Recent work shows that active RIP1 kinase can drive…