![](https://www.Immune-System-Research.com/"wp-content/uploads"/2023/05/PRE-084-is-a-S1R-Agonist-for-Cardiovascular-and-Neurological-Disease-Research-20230524.jpg)
The sigma-1 receptor (σ1R， S1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER)…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2023/05/MR2938-is-a-Potent-AChE-Inhibitor-for-Alzheimers-Disease-Research-20230519.jpg)
AChE and BChE are hydrolases of the neurotransmitter acetylcholine (ACh). Alzheimer’s disease is a devastating neurodegenerative disease characterized by memory and…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2023/05/SD-6-is-an-Orally-Active-hAChEhBChE-Inhibitor-for-Alzheimers-Disease-Research-2023-0512.jpg)
Alzheimer’s disease (AD) is the most common form of dementia. The cholinesterase enzymes (ChEs), i.e., AChE and butyrylcholine esterase (BChE)…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2023/04/Yonkenafil-Tunodafil-is-a-PDE5-Inhibitor-for-Alzheimers-Disease-Research-2023-0506.jpg)
Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic phosphodiester bonds, breaking them down into monophosphates and nucleotides. This…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2023/04/TC-2153-is-STEP-Inhibitor-with-Antidepressant-Activity-and-Low-Acute-Toxicity-2023-0421.jpg)
Striatal-enriched protein tyrosine phosphatase (STEP) is a CNS-rich protein associated with a variety of neurological and neuropsychiatric disorders. Firstly, it…