Finerenone is an MR Antagonist for Cardiorenal Diseases Research
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is…
Dapagliflozin is a SGLT2 Inhibitor for Diabetes Mellitus Research
SGLT2 (glucose cotransporter 2, also known as SLC5A2) is a member of the sodium-glucose cotransporter family and belongs to the sodium-dependent glucose transporters. SGLT2 is mostly located in the brush-like…
AZD1092 is an Orally Active GK Activator for the Research of Type 2 Diabetes
Glucokinase is a hexokinase isozyme that facilitates phosphorylation of glucose to glucose-6-phosphate. This is the rate-limiting step in glucose metabolism. Glucokinase occurs in cells in the liver and pancreas of…
Sotagliflozin (LX-4211) is a SGLT2/1 Inhibitor for Type 2 Diabetes Research
In this article, we will introduce a potent and orally available SGLT2/1 Inhibitor, Sotagliflozin (LX-4211). It exhibits IC50 values of 0.0018 µΜ and 0.036 µM for SGLT-2 and SGLT-1, respectively. Sotagliflozin's…
BT44 is an RET Activator for Neurodegenerative Disorders and Diabetes Mellitus Research
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) alleviate symptoms of experimental neuropathy, protect and stimulate the regeneration of sensory neurons in animal models of neuropathic pain, and…
SB-435495 is an Orally Active Lp-PLA2 Inhibitor for Diabetes Research
Lp-PLA2 (Lipoprotein-associated phospholipase A2) is a calcium-independent serine lipase of 50-kDa that hydrolyzes the acetyl group at the sn-2 position of the platelet-activating factor. Importantly, Lp-PLA2 circulates in plasma bound…
Tirzepatide (LY3298176) is a Dual GIP and GLP-1 Receptor Agonist for Type 2 Diabetes Research
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders worldwide. Furthermore, cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with T2DM.…
Empagliflozin (BI 107730) is a Selective SGLT-2 Inhibitor for Type 2 Diabetes Research
Diabetes has a major impact on the global human population. Generally, blood glucose control is the major method of diabetes treatment. Previous studies indicated that targeting sodium glucose co-transporter-2 (SGLT-2)…
Midaglizole is a Potent α2-Adrenoceptor Antagonist with a Hypoglycemic Activity
α2-adrenoceptor is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. Besides, the α2-adrenoceptor not only inhibits the release of their neurotransmitters (autoreceptors) but can also regulate the…