Finerenone is an MR Antagonist for Cardiorenal Diseases Research
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is…
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is…
SGLT2 (glucose cotransporter 2, also known as SLC5A2) is a member of the sodium-glucose cotransporter family and belongs to the sodium-dependent glucose transporters. SGLT2 is mostly located in the brush-like…
Glucokinase is a hexokinase isozyme that facilitates phosphorylation of glucose to glucose-6-phosphate. This is the rate-limiting step in glucose metabolism. Glucokinase occurs in cells in the liver and pancreas of…
In this article, we will introduce a potent and orally available SGLT2/1 Inhibitor, Sotagliflozin (LX-4211). It exhibits IC50 values of 0.0018 µΜ and 0.036 µM for SGLT-2 and SGLT-1, respectively. Sotagliflozin's…
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) alleviate symptoms of experimental neuropathy, protect and stimulate the regeneration of sensory neurons in animal models of neuropathic pain, and…
Lp-PLA2 (Lipoprotein-associated phospholipase A2) is a calcium-independent serine lipase of 50-kDa that hydrolyzes the acetyl group at the sn-2 position of the platelet-activating factor. Importantly, Lp-PLA2 circulates in plasma bound…
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders worldwide. Furthermore, cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with T2DM.…
Diabetes has a major impact on the global human population. Generally, blood glucose control is the major method of diabetes treatment. Previous studies indicated that targeting sodium glucose co-transporter-2 (SGLT-2)…
α2-adrenoceptor is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. Besides, the α2-adrenoceptor not only inhibits the release of their neurotransmitters (autoreceptors) but can also regulate the…